KMID : 0359320120520010053
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Korean Journal of Veterinary Research 2012 Volume.52 No. 1 p.53 ~ p.56
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Studies on the anti-parasitic efficacy and safety of ivermectin and pyrantel pamoate compound against Dirofilaria immitis in dogs
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Youn Hee-Jeong
Lim Yong-Suk Kim Kyong-Hee Lee Kyong-Eun Ra Jeong-Chan Kim Byung-Ki
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Abstract
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Dirofilaria (D.) immitis is an important canine parasitic nematode in dogs. D. immitis parasitizes the right ventricle and pulmonary artery of dogs. An ivermectin and pyrantel pamoate compound (IPPC) was administered to dogs naturally infected with this parasite. IPPC is composed of 68.0, 136.0 and 272.0 ¥ìg of ivermectin and 57.0, 114.0 and 227.0 mg pyrantel pamoate for small, middle, and large animals. Ivermectin has activity against nematodes and ectoparasites in dogs. Pyrantel pamoate is also effective against nematodes in dogs. Our results showed that this drug combination has good efficacy in D. immitis infected dogs.
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KEYWORD
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Dirofilaria immitis, ivermectin, ivermectin and pyrantel pamoate compound, pyrantel pamoate
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